{"symbol":"MSH2","synonyms":["COCA1","LCFS2","FCC1","HNPCC1","hMSH2"],"name":"mutS homolog 2","description":"This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]","ncbiEntrezGeneId":4436,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/4436","proteins":[{"symbol":"MSH2_HUMAN","href":"/api/1.0/protein/MSH2_HUMAN"}],"hgncRootFamilies":[]}