{"symbol":"MSH4","synonyms":[],"name":"mutS homolog 4","description":"This gene encodes a member of the DNA mismatch repair mutS family. This member is a meiosis-specific protein that is not involved in DNA mismatch correction, but is required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis I. This protein and MSH5 form a heterodimer which binds uniquely to a Holliday Junction and its developmental progenitor, thus provoking ADP-ATP exchange, and stabilizing the interaction between parental chromosomes during meiosis double-stranded break repair. [provided by RefSeq, Aug 2011]","ncbiEntrezGeneId":4438,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/4438","proteins":[{"symbol":"MSH4_HUMAN","href":"/api/1.0/protein/MSH4_HUMAN"}],"hgncRootFamilies":[]}