{"symbol":"MSL3","synonyms":["MSL3L1"],"name":"male-specific lethal 3 homolog (Drosophila)","description":"This gene encodes a nuclear protein that is similar to the product of the Drosophila male-specific lethal-3 gene. The Drosophila protein plays a critical role in a dosage-compensation pathway, which equalizes X-linked gene expression in males and females. Thus, the human protein is thought to play a similar function in chromatin remodeling and transcriptional regulation, and it has been found as part of a complex that is responsible for histone H4 lysine-16 acetylation. This gene can undergo X inactivation. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 7 and 8. [provided by RefSeq, Jul 2010]","ncbiEntrezGeneId":10943,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/10943","proteins":[{"symbol":"MS3L1_HUMAN","href":"/api/1.0/protein/MS3L1_HUMAN"}],"hgncRootFamilies":[]}