{"symbol":"MSX2","synonyms":["PFM","CRS2","HOX8","FPP","MSH"],"name":"msh homeobox 2","description":"This gene encodes a member of the muscle segment homeobox gene family. The encoded protein is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis. The encoded protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways. Mutations in this gene are associated with parietal foramina 1 and craniosynostosis type 2. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":4488,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/4488","proteins":[{"symbol":"MSX2_HUMAN","href":"/api/1.0/protein/MSX2_HUMAN"}],"hgncRootFamilies":[{"name":"Homeoboxes","href":"/api/1.0/gene_family/Homeoboxes"}]}