{"symbol":"MTRR","synonyms":["CBLE","MSR"],"name":"5-methyltetrahydrofolate-homocysteine methyltransferase reductase","description":"This gene encodes a member of the ferredoxin-NADP(+) reductase (FNR) family of electron transferases. This protein functions in the synthesis of methionine by regenerating methionine synthase to a functional state. Because methionine synthesis requires methyl-group transfer by a folate donor, activity of the encoded enzyme is important for folate metabolism and cellular methylation. Mutations in this gene can cause homocystinuria-megaloblastic anemia, cbl E type. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]","ncbiEntrezGeneId":4552,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/4552","proteins":[{"symbol":"MTRR_HUMAN","href":"/api/1.0/protein/MTRR_HUMAN"}],"hgncRootFamilies":[]}