{"symbol":"MUC21","synonyms":["C6ORF205","KMQK697","MUC-21"],"name":"mucin 21, cell surface associated","description":"This gene encodes a large membrane-bound glycoprotein which is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. The encoded protein contains an N-terminal signal sequence, an extracellular mucin domain, a stem domain, a transmembrane domain, and a C-terminal cytoplasmic tail domain. The mucin domain contains O-glycosylation sites and is polymorphic with isoforms containing a variable number of nonidentical proline-, threonine-, and serine-rich tandem repeats of 15 amino acids each. The aberrent expression of this gene is associated with lung adenocarcinoma. [provided by RefSeq, May 2017]","ncbiEntrezGeneId":394263,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/394263","proteins":[{"symbol":"MUC21_HUMAN","href":"/api/1.0/protein/MUC21_HUMAN"}],"hgncRootFamilies":[{"name":"Mucins (MUC)","href":"/api/1.0/gene_family/Mucins+%28MUC%29"}]}