{"symbol":"MUS81","synonyms":["SLX3"],"name":"MUS81 structure-specific endonuclease subunit","description":"This gene encodes a structure-specific endonuclease which belongs to the XPF/MUS81 endonuclease family and plays a critical role in the resolution of recombination intermediates during DNA repair after inter-strand cross-links, replication fork collapse, and DNA double-strand breaks. The encoded protein associates with one of two closely related essential meiotic endonuclease proteins (EME1 or EME2) to form a complex that processes DNA secondary structures. It contains an N-terminal DEAH helicase domain, an excision repair cross complementation group 4 (ERCC4) endonuclease domain, and two tandem C-terminal helix-hairpin-helix domains. Mice with a homozygous knockout of the orthologous gene have significant meiotic defects including the failure to repair a subset of DNA double strand breaks. [provided by RefSeq, Jun 2017]","ncbiEntrezGeneId":80198,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/80198","proteins":[{"symbol":"MUS81_HUMAN","href":"/api/1.0/protein/MUS81_HUMAN"}],"hgncRootFamilies":[]}