{"symbol":"MVP","synonyms":["VAULT1"],"name":"major vault protein","description":"This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]","ncbiEntrezGeneId":9961,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/9961","proteins":[{"symbol":"MVP_HUMAN","href":"/api/1.0/protein/MVP_HUMAN"}],"hgncRootFamilies":[]}