{"symbol":"MXD3","synonyms":["MYX","BHLHC13","MAD3"],"name":"MAX dimerization protein 3","description":"This gene encodes a member of the Myc superfamily of basic helix-loop-helix leucine zipper transcriptional regulators. The encoded protein forms a heterodimer with the cofactor MAX which binds specific E-box DNA motifs in the promoters of target genes and regulates their transcription. Disruption of the MAX-MXD3 complex is associated with uncontrolled cell proliferation and tumorigenesis. Transcript variants of this gene encoding different isoforms have been described.[provided by RefSeq, Dec 2008]","ncbiEntrezGeneId":83463,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/83463","proteins":[{"symbol":"MAD3_HUMAN","href":"/api/1.0/protein/MAD3_HUMAN"}],"hgncRootFamilies":[{"name":"Basic helix-loop-helix proteins (BHLH)","href":"/api/1.0/gene_family/Basic+helix-loop-helix+proteins+%28BHLH%29"},{"name":"MAX dimerization proteins (MXD)","href":"/api/1.0/gene_family/MAX+dimerization+proteins+%28MXD%29"}]}