{"symbol":"MXD4","synonyms":["MAD4","BHLHC12","MST149","MSTP149"],"name":"MAX dimerization protein 4","description":"This gene is a member of the MAD gene family . The MAD genes encode basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein, forming a transcriptional repression complex. The MAD proteins compete for MAX binding with MYC, which heterodimerizes with MAX forming a transcriptional activation complex. Studies in rodents suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in differentiating tissues. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":10608,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/10608","proteins":[{"symbol":"MAD4_HUMAN","href":"/api/1.0/protein/MAD4_HUMAN"}],"hgncRootFamilies":[{"name":"Basic helix-loop-helix proteins (BHLH)","href":"/api/1.0/gene_family/Basic+helix-loop-helix+proteins+%28BHLH%29"},{"name":"MAX dimerization proteins (MXD)","href":"/api/1.0/gene_family/MAX+dimerization+proteins+%28MXD%29"}]}