{"symbol":"MYD88","synonyms":["MYD88D"],"name":"myeloid differentiation primary response 88","description":"This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]","ncbiEntrezGeneId":4615,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/4615","proteins":[{"symbol":"MYD88_HUMAN","href":"/api/1.0/protein/MYD88_HUMAN"}],"hgncRootFamilies":[]}