{"symbol":"MYH11","synonyms":["AAT4","FAA4","SMMHC","SMHC"],"name":"myosin, heavy chain 11, smooth muscle","description":"The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. A chromosomal rearrangement involving this gene is associated with acute myeloid leukemia of the M4Eo subtype. Mutations in this gene are associated with visceral myopathy, megacystis-microcolon-intestinal hypoperistalsis syndrome 2, and familial thoracic aortic aneurysm 4. [provided by RefSeq, May 2022]","ncbiEntrezGeneId":4629,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/4629","proteins":[{"symbol":"MYH11_HUMAN","href":"/api/1.0/protein/MYH11_HUMAN"}],"hgncRootFamilies":[{"name":"Myosins (MYH, MYO)","href":"/api/1.0/gene_family/Myosins+%28MYH%2C+MYO%29"}]}