{"symbol":"MYO9B","synonyms":["MYR5","CELIAC4"],"name":"myosin IXB","description":"This gene encodes a member of the myosin family of actin-based molecular motor heavy chain proteins. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). The protein has four IQ motifs located in the neck domain that bind calmodulin, which serves as a light chain. The protein complex has a single-headed structure and exhibits processive movement on actin filaments toward the minus-end. The protein also has rho-GTPase activity. Polymorphisms in this gene are associated with celiac disease and ulcerative colitis susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]","ncbiEntrezGeneId":4650,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/4650","proteins":[{"symbol":"MYO9B_HUMAN","href":"/api/1.0/protein/MYO9B_HUMAN"}],"hgncRootFamilies":[{"name":"Myosins (MYH, MYO)","href":"/api/1.0/gene_family/Myosins+%28MYH%2C+MYO%29"}]}