{"symbol":"MYOC","synonyms":["JOAG","GLC1A","GPOA","JOAG1","TIGR","MYOCILIN"],"name":"myocilin, trabecular meshwork inducible glucocorticoid response","description":"MYOC encodes the protein myocilin, which is believed to have a role in cytoskeletal function. MYOC is expressed in many occular tissues, including the trabecular meshwork, and was revealed to be the trabecular meshwork glucocorticoid-inducible response protein (TIGR). The trabecular meshwork is a specialized eye tissue essential in regulating intraocular pressure, and mutations in MYOC have been identified as the cause of hereditary juvenile-onset open-angle glaucoma. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":4653,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/4653","proteins":[{"symbol":"MYOC_HUMAN","href":"/api/1.0/protein/MYOC_HUMAN"}],"hgncRootFamilies":[]}