{"symbol":"NCOA1","synonyms":["RIP160","BHLHE74","F-SRC-1","KAT13A"],"name":"nuclear receptor coactivator 1","description":"The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":8648,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/8648","proteins":[{"symbol":"NCOA1_HUMAN","href":"/api/1.0/protein/NCOA1_HUMAN"}],"hgncRootFamilies":[{"name":"Chromatin-modifying enzymes","href":"/api/1.0/gene_family/Chromatin-modifying+enzymes"},{"name":"Basic helix-loop-helix proteins (BHLH)","href":"/api/1.0/gene_family/Basic+helix-loop-helix+proteins+%28BHLH%29"}]}