{"symbol":"NCOR1","synonyms":["TRAC1","N-COR1","PPP1R109","N-COR","HN-COR"],"name":"nuclear receptor corepressor 1","description":"This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.[provided by RefSeq, Jun 2010]","ncbiEntrezGeneId":9611,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/9611","proteins":[{"symbol":"NCOR1_HUMAN","href":"/api/1.0/protein/NCOR1_HUMAN"}],"hgncRootFamilies":[{"name":"SANT/Myb domain containing","href":"/api/1.0/gene_family/SANT%24slash%24Myb+domain+containing"},{"name":"Protein phosphatase 1 regulatory subunits (PPP1R)","href":"/api/1.0/gene_family/Protein+phosphatase+1+regulatory+subunits+%28PPP1R%29"}]}