{"symbol":"NDE1","synonyms":["NUDE1","NDE","MHAC","NUDE","HOM-TES-87","LIS4"],"name":"nudE neurodevelopment protein 1","description":"This gene encodes a member of the nuclear distribution E (NudE) family of proteins. The encoded protein is localized at the centrosome and interacts with other centrosome components as part of a multiprotein complex that regulates dynein function. This protein plays an essential role in microtubule organization, mitosis and neuronal migration. Mutations in this gene cause lissencephaly 4, a disorder characterized by lissencephaly, severe brain atrophy, microcephaly, and severe cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]","ncbiEntrezGeneId":54820,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/54820","proteins":[{"symbol":"NDE1_HUMAN","href":"/api/1.0/protein/NDE1_HUMAN"}],"hgncRootFamilies":[]}