{"symbol":"NDRG1","synonyms":["CAP43","HMSNL","RIT42","DRG-1","TARG1","RTP","NDR1","GC4","DRG1","TDD5","PROXY1","NMSL","CMT4D"],"name":"N-myc downstream regulated 1","description":"This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. The encoded protein is necessary for p53-mediated caspase activation and apoptosis. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4D, and expression of this gene may be a prognostic indicator for several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]","ncbiEntrezGeneId":10397,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/10397","proteins":[{"symbol":"NDRG1_HUMAN","href":"/api/1.0/protein/NDRG1_HUMAN"}],"hgncRootFamilies":[]}