{"symbol":"NDUFA1","synonyms":["CI-MWFE","ZNF183","MWFE"],"name":"NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa","description":"The human NDUFA1 gene codes for an essential component of complex I of the respiratory chain, which transfers electrons from NADH to ubiquinone. It has been noted that the N-terminal hydrophobic domain has the potential to be folded into an alpha-helix spanning the inner mitochondrial membrane with a C-terminal hydrophilic domain interacting with globular subunits of complex I. The highly conserved two-domain structure suggests that this feature is critical for the protein function and might act as an anchor for the NADH:ubiquinone oxidoreductase complex at the inner mitochondrial membrane. However, the NDUFA1 peptide is one of about 31 components of the `hydrophobic protein` (HP) fraction of complex I which is involved in proton translocation. Thus the NDUFA1 peptide may also participate in that function. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":4694,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/4694","proteins":[{"symbol":"NDUA1_HUMAN","href":"/api/1.0/protein/NDUA1_HUMAN"}],"hgncRootFamilies":[{"name":"Mitochondrial respiratory chain complexes","href":"/api/1.0/gene_family/Mitochondrial+respiratory+chain+complexes"}]}