{"symbol":"NDUFB9","synonyms":["LYRM3","UQOR22","CI-B22","B22"],"name":"NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa","description":"The protein encoded by this gene is a subunit of the mitochondrial oxidative phosphorylation complex I (nicotinamide adenine dinucleotide: ubiquinone oxidoreductase). Complex I is localized to the inner mitochondrial membrane and functions to dehydrogenate nicotinamide adenine dinucleotide and to shuttle electrons to coenzyme Q. Complex I deficiency is the most common defect found in oxidative phosphorylation disorders and results in a range of conditions, including lethal neonatal disease, hypertrophic cardiomyopathy, liver disease, and adult-onset neurodegenerative disorders. Pseudogenes of this gene are found on chromosomes five, seven and eight. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]","ncbiEntrezGeneId":4715,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/4715","proteins":[{"symbol":"NDUB9_HUMAN","href":"/api/1.0/protein/NDUB9_HUMAN"}],"hgncRootFamilies":[{"name":"Mitochondrial respiratory chain complexes","href":"/api/1.0/gene_family/Mitochondrial+respiratory+chain+complexes"},{"name":"LYR motif containing (LYRM)","href":"/api/1.0/gene_family/LYR+motif+containing+%28LYRM%29"}]}