{"symbol":"NECAB3","synonyms":["DJ63M2.4","XB51","EFCBP3","DJ63M2.5","SYTIP2","APBA2BP","STIP3"],"name":"N-terminal EF-hand calcium binding protein 3","description":"The protein encoded by this gene interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. The protein is phosphorylated by NIMA-related expressed kinase 2, and localizes to the Golgi apparatus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":63941,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/63941","proteins":[{"symbol":"NECA3_HUMAN","href":"/api/1.0/protein/NECA3_HUMAN"}],"hgncRootFamilies":[{"name":"EF-hand domain containing","href":"/api/1.0/gene_family/EF-hand+domain+containing"}]}