{"symbol":"NEDD4","synonyms":["NEDD4-1","RPF1"],"name":"neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase","description":"This gene is the founding member of the NEDD4 family of HECT ubiquitin ligases that function in the ubiquitin proteasome system of protein degradation. The encoded protein contains an N-terminal calcium and phospholipid binding C2 domain followed by multiple tryptophan-rich WW domains and, a C-terminal HECT ubiquitin ligase catalytic domain. It plays critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumor suppressor PTEN. [provided by RefSeq, Jul 2016]","ncbiEntrezGeneId":4734,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/4734","proteins":[{"symbol":"NEDD4_HUMAN","href":"/api/1.0/protein/NEDD4_HUMAN"}],"hgncRootFamilies":[]}