{"symbol":"NELFA","synonyms":["P/OKCL.15","WHSC2","NELF-A"],"name":"negative elongation factor complex member A","description":"This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":7469,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/7469","proteins":[{"symbol":"NELFA_HUMAN","href":"/api/1.0/protein/NELFA_HUMAN"}],"hgncRootFamilies":[]}