{"symbol":"NFKB1","synonyms":["NFKB-P50","NF-KAPPA-B","KBF1","CVID12","NF-kappa-B1","NFKB-P105","NF-KB1","EBP-1","NFKAPPAB","NF-KAPPAB"],"name":"nuclear factor of kappa light polypeptide gene enhancer in B-cells 1","description":"This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. NFKB is a critical regulator of the immediate-early response to viral infection. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed. [provided by RefSeq, Aug 2020]","ncbiEntrezGeneId":4790,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/4790","proteins":[{"symbol":"NFKB1_HUMAN","href":"/api/1.0/protein/NFKB1_HUMAN"}],"hgncRootFamilies":[{"name":"Ankyrin repeat domain containing (ANKRD)","href":"/api/1.0/gene_family/Ankyrin+repeat+domain+containing+%28ANKRD%29"}]}