{"symbol":"NFKBIA","synonyms":["MAD-3","NFKBI","IKBA"],"name":"nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha","description":"This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease. [provided by RefSeq, Aug 2011]","ncbiEntrezGeneId":4792,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/4792","proteins":[{"symbol":"IKBA_HUMAN","href":"/api/1.0/protein/IKBA_HUMAN"}],"hgncRootFamilies":[{"name":"Ankyrin repeat domain containing (ANKRD)","href":"/api/1.0/gene_family/Ankyrin+repeat+domain+containing+%28ANKRD%29"}]}