{"symbol":"NFKBIZ","synonyms":["MAIL","IKBZ","INAP"],"name":"nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta","description":"This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":64332,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/64332","proteins":[{"symbol":"IKBZ_HUMAN","href":"/api/1.0/protein/IKBZ_HUMAN"}],"hgncRootFamilies":[{"name":"Ankyrin repeat domain containing (ANKRD)","href":"/api/1.0/gene_family/Ankyrin+repeat+domain+containing+%28ANKRD%29"}]}