{"symbol":"NFX1","synonyms":["NFX2","TEX42","TEG-42"],"name":"nuclear transcription factor, X-box binding 1","description":"MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three alternative splice variants, each of which encodes a different isoform, have been identified. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":4799,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/4799","proteins":[{"symbol":"NFX1_HUMAN","href":"/api/1.0/protein/NFX1_HUMAN"}],"hgncRootFamilies":[]}