{"symbol":"NLRP10","synonyms":["NOD8","PAN5","PYNOD","CLR11.1","NALP10"],"name":"NLR family, pyrin domain containing 10","description":"Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as a multifunctional negative regulator of inflammation and apoptosis. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":338322,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/338322","proteins":[{"symbol":"NAL10_HUMAN","href":"/api/1.0/protein/NAL10_HUMAN"}],"hgncRootFamilies":[{"name":"NLR family (NLR)","href":"/api/1.0/gene_family/NLR+family+%28NLR%29"}]}