{"symbol":"NLRP4","synonyms":["PYPAF4","NALP4","CLR19.5","RNH2"],"name":"NLR family, pyrin domain containing 4","description":"The protein encoded by this gene is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family, and is predicted to contain an N-terminal pyrin effector domain (PYD), a centrally-located nucleotide-binding and oligomerization domain (NACHT) and C-terminal leucine-rich repeats (LRR). This gene product has a demonstrated role as a negative regulator of autophagy and type I interferon signaling pathways as a result of protein interactions with its NACHT domain. The PYD domain has also been shown to be important in the inhibition of NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells). [provided by RefSeq, Dec 2016]","ncbiEntrezGeneId":147945,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/147945","proteins":[{"symbol":"NALP4_HUMAN","href":"/api/1.0/protein/NALP4_HUMAN"}],"hgncRootFamilies":[{"name":"NLR family (NLR)","href":"/api/1.0/gene_family/NLR+family+%28NLR%29"}]}