{"symbol":"NLRP7","synonyms":["PAN7","PYPAF3","CLR19.4","HYDM","NALP7","NOD12"],"name":"NLR family, pyrin domain containing 7","description":"This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. This gene may act as a feedback regulator of caspase-1-dependent interleukin 1-beta secretion. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":199713,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/199713","proteins":[{"symbol":"NALP7_HUMAN","href":"/api/1.0/protein/NALP7_HUMAN"}],"hgncRootFamilies":[{"name":"NLR family (NLR)","href":"/api/1.0/gene_family/NLR+family+%28NLR%29"}]}