{"symbol":"NPLOC4","synonyms":["NPL4"],"name":"nuclear protein localization 4 homolog (S. cerevisiae)","description":"Predicted to enable ubiquitin binding activity and ubiquitin protein ligase binding activity. Predicted to contribute to K48-linked polyubiquitin modification-dependent protein binding activity and K63-linked polyubiquitin modification-dependent protein binding activity. Involved in negative regulation of RIG-I signaling pathway; negative regulation of type I interferon production; and proteolysis involved in protein catabolic process. Located in nucleus. Part of UFD1-NPL4 complex and VCP-NPL4-UFD1 AAA ATPase complex. [provided by Alliance of Genome Resources, Mar 2025]","ncbiEntrezGeneId":55666,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/55666","proteins":[{"symbol":"NPL4_HUMAN","href":"/api/1.0/protein/NPL4_HUMAN"}],"hgncRootFamilies":[{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"}]}