{"symbol":"NPR2","synonyms":["GUCY2B","ANPRB","SNSK","ECDM","NPRB","AMDM","GUC2B","ANPB","NPRBI"],"name":"natriuretic peptide receptor 2","description":"This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":4882,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/4882","proteins":[{"symbol":"ANPRB_HUMAN","href":"/api/1.0/protein/ANPRB_HUMAN"}],"hgncRootFamilies":[{"name":"DENN/MADD domain containing (DENND)","href":"/api/1.0/gene_family/DENN%24slash%24MADD+domain+containing+%28DENND%29"}]}