{"symbol":"NPTX2","synonyms":["NARP","NP-II","NP2"],"name":"neuronal pentraxin II","description":"This gene encodes a member of the family of neuronal petraxins, synaptic proteins that are related to C-reactive protein. This protein is involved in excitatory synapse formation. It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells. Up-regulation of this gene in Parkinson disease (PD) tissues suggests that the protein may be involved in the pathology of PD. [provided by RefSeq, Feb 2009]","ncbiEntrezGeneId":4885,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/4885","proteins":[{"symbol":"NPTX2_HUMAN","href":"/api/1.0/protein/NPTX2_HUMAN"}],"hgncRootFamilies":[]}