{"symbol":"NR2C2","synonyms":["TR4"],"name":"nuclear receptor subfamily 2, group C, member 2","description":"This gene encodes a protein that belongs to the nuclear hormone receptor family. Members of this family act as ligand-activated transcription factors and function in many biological processes such as development, cellular differentiation and homeostasis. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes. The protein encoded by this gene plays a role in protecting cells from oxidative stress and damage induced by ionizing radiation. The lack of a similar gene in mouse results in growth retardation, severe spinal curvature, subfertility, premature aging, and prostatic intraepithelial neoplasia (PIN) development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]","ncbiEntrezGeneId":7182,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/7182","proteins":[{"symbol":"NR2C2_HUMAN","href":"/api/1.0/protein/NR2C2_HUMAN"}],"hgncRootFamilies":[{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"}]}