{"symbol":"NRAS","synonyms":["NCMS","NRAS1","N-RAS","CMNS","NS6","ALPS4"],"name":"neuroblastoma RAS viral (v-ras) oncogene homolog","description":"This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011]","ncbiEntrezGeneId":4893,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/4893","proteins":[{"symbol":"RASN_HUMAN","href":"/api/1.0/protein/RASN_HUMAN"}],"hgncRootFamilies":[{"name":"Ras small GTPases superfamily","href":"/api/1.0/gene_family/Ras+small+GTPases+superfamily"}]}