{"symbol":"NRP1","synonyms":["CD304","BDCA4","VEGF165R"],"name":"neuropilin 1","description":"This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. This protein has also been determined to act as a co-receptor for SARS-CoV-2 (which causes COVID-19) to infect host cells. [provided by RefSeq, Nov 2020]","ncbiEntrezGeneId":8829,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/8829","proteins":[{"symbol":"NRP1_HUMAN","href":"/api/1.0/protein/NRP1_HUMAN"}],"hgncRootFamilies":[{"name":"CD molecules (CD)","href":"/api/1.0/gene_family/CD+molecules+%28CD%29"}]}