{"symbol":"NSMAF","synonyms":["GRAMD5","FAN"],"name":"neutral sphingomyelinase (N-SMase) activation associated factor","description":"This gene encodes a WD-repeat protein that binds the cytoplasmic sphingomyelinase activation domain of the 55kD tumor necrosis factor receptor. This protein is required for TNF-mediated activation of neutral sphingomyelinase and may play a role in regulating TNF-induced cellular responses such as inflammation. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]","ncbiEntrezGeneId":8439,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/8439","proteins":[{"symbol":"FAN_HUMAN","href":"/api/1.0/protein/FAN_HUMAN"}],"hgncRootFamilies":[{"name":"WD repeat domain containing (WDR)","href":"/api/1.0/gene_family/WD+repeat+domain+containing+%28WDR%29"}]}