{"symbol":"NUDT15","synonyms":["NUDT15D","MTH2"],"name":"nudix (nucleoside diphosphate linked moiety X)-type motif 15","description":"This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base mispairing during DNA replication, causing transversions. The encoded enzyme is a negative regulator of thiopurine activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early leukopenia. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Apr 2016]","ncbiEntrezGeneId":55270,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/55270","proteins":[{"symbol":"NUD15_HUMAN","href":"/api/1.0/protein/NUD15_HUMAN"}],"hgncRootFamilies":[{"name":"Nudix type motif-containing (NUDT)","href":"/api/1.0/gene_family/Nudix+type+motif-containing+%28NUDT%29"}]}