{"symbol":"NUDT5","synonyms":["HYSAH1","YSA1","hNUDT5","YSA1H","YSAH1"],"name":"nudix (nucleoside diphosphate linked moiety X)-type motif 5","description":"This gene belongs to the Nudix (nucleoside diphosphate linked moiety X) hydrolase superfamily. The encoded enzyme catalyzes the hydrolysis of modified nucleoside diphosphates, including ADP-ribose (ADPR) and 8-oxoGua-containing 8-oxo-dADP and 8-oxo-dGDP. Protein-bound ADP ribose can be hazardous to the cell because it can modify some amino acid residues, resulting in the inhibition of ATP-activated potassium channels. 8-oxoGua is an oxidized form of guanine that can potentially alter genetic information by pairing with adenine and cytosine in RNA. Presence of 8-oxoGua in RNA results in formation of abnormal proteins due to translational errors. [provided by RefSeq, Aug 2013]","ncbiEntrezGeneId":11164,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/11164","proteins":[{"symbol":"NUDT5_HUMAN","href":"/api/1.0/protein/NUDT5_HUMAN"}],"hgncRootFamilies":[{"name":"Nudix type motif-containing (NUDT)","href":"/api/1.0/gene_family/Nudix+type+motif-containing+%28NUDT%29"}]}