{"symbol":"OAS2","synonyms":[],"name":"2\u0027-5\u0027-oligoadenylate synthetase 2, 69/71kDa","description":"This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2\u0027-specific nucleotidyl transfer reactions to synthesize 2\u0027,5\u0027-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":4939,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/4939","proteins":[{"symbol":"OAS2_HUMAN","href":"/api/1.0/protein/OAS2_HUMAN"}],"hgncRootFamilies":[]}