{"symbol":"OLIG2","synonyms":["BHLHE19","BHLHB1","RACK17","OLIGO2","PRKCBP2"],"name":"oligodendrocyte lineage transcription factor 2","description":"This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":10215,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/10215","proteins":[{"symbol":"OLIG2_HUMAN","href":"/api/1.0/protein/OLIG2_HUMAN"}],"hgncRootFamilies":[{"name":"Basic helix-loop-helix proteins (BHLH)","href":"/api/1.0/gene_family/Basic+helix-loop-helix+proteins+%28BHLH%29"}]}