{"symbol":"OSM","synonyms":[],"name":"oncostatin M","description":"This gene encodes a member of the leukemia inhibitory factor/oncostatin-M (LIF/OSM) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a secreted cytokine and growth regulator that inhibits the proliferation of a number of tumor cell lines. This protein also regulates the production of other cytokines, including interleukin 6, granulocyte-colony stimulating factor and granulocyte-macrophage colony stimulating factor in endothelial cells. This gene and the related gene, leukemia inhibitory factor, also present on chromosome 22, may have resulted from the duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]","ncbiEntrezGeneId":5008,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5008","proteins":[{"symbol":"ONCM_HUMAN","href":"/api/1.0/protein/ONCM_HUMAN"}],"hgncRootFamilies":[]}