{"symbol":"OTUD5","synonyms":["DUBA"],"name":"OTU deubiquitinase 5","description":"This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Oct 2008]","ncbiEntrezGeneId":55593,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/55593","proteins":[{"symbol":"OTUD5_HUMAN","href":"/api/1.0/protein/OTUD5_HUMAN"}],"hgncRootFamilies":[{"name":"OTU domain containing (OTUD)","href":"/api/1.0/gene_family/OTU+domain+containing+%28OTUD%29"}]}