{"symbol":"OTULIN","synonyms":["AIPDS","FAM105B","GUM"],"name":"OTU deubiquitinase with linear linkage specificity","description":"This gene encodes a member of the peptidase C65 family of ubiquitin isopeptidases. Members of this family remove ubiquitin from proteins. The encoded enzyme specifically recognizes and removes M1(Met1)-linked, or linear, ubiquitin chains from protein substrates. Linear ubiquitin chains are known to regulate the NF-kappa B signaling pathway in the context of immunity and inflammation. Mutations in this gene cause a potentially fatal autoinflammatory syndrome in human patients. [provided by RefSeq, Sep 2016]","ncbiEntrezGeneId":90268,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/90268","proteins":[{"symbol":"OTUL_HUMAN","href":"/api/1.0/protein/OTUL_HUMAN"}],"hgncRootFamilies":[{"name":"OTU domain containing (OTUD)","href":"/api/1.0/gene_family/OTU+domain+containing+%28OTUD%29"}]}