{"symbol":"P2RX3","synonyms":["P2X3"],"name":"purinergic receptor P2X, ligand gated ion channel, 3","description":"This gene encodes a member of the P2X purinergic receptor (purinoceptor) gene family which includes seven members (P2RX1 - P2RX7). P2X purinoceptors are a family of cation-permeable, ligand-gated ion channels that open in response to the binding of extracellular adenosine 5\u0027-triphosphate (ATP). The encoded protein is a subunit of the trimeric P2X3 receptor ion channel which is expressed by sensory or autonomic neurons. A deficiency of the orthologous protein in mice is associated with reduced pain-related behavior and urinary bladder hyporeflexia. [provided by RefSeq, Aug 2017]","ncbiEntrezGeneId":5024,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5024","proteins":[{"symbol":"P2RX3_HUMAN","href":"/api/1.0/protein/P2RX3_HUMAN"}],"hgncRootFamilies":[{"name":"Purinergic receptors (P2R)","href":"/api/1.0/gene_family/Purinergic+receptors+%28P2R%29"},{"name":"Ion channels","href":"/api/1.0/gene_family/Ion+channels"}]}