{"symbol":"P2RX6","synonyms":["P2XM","P2RXL1","P2X6"],"name":"purinergic receptor P2X, ligand gated ion channel, 6","description":"The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 22, has been identified. [provided by RefSeq, Apr 2009]","ncbiEntrezGeneId":9127,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/9127","proteins":[{"symbol":"P2RX6_HUMAN","href":"/api/1.0/protein/P2RX6_HUMAN"}],"hgncRootFamilies":[{"name":"Ion channels","href":"/api/1.0/gene_family/Ion+channels"},{"name":"Purinergic receptors (P2R)","href":"/api/1.0/gene_family/Purinergic+receptors+%28P2R%29"}]}