{"symbol":"P2RX7","synonyms":["P2X7"],"name":"purinergic receptor P2X, ligand gated ion channel, 7","description":"The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2010]","ncbiEntrezGeneId":5027,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5027","proteins":[{"symbol":"P2RX7_HUMAN","href":"/api/1.0/protein/P2RX7_HUMAN"}],"hgncRootFamilies":[{"name":"Purinergic receptors (P2R)","href":"/api/1.0/gene_family/Purinergic+receptors+%28P2R%29"},{"name":"Ion channels","href":"/api/1.0/gene_family/Ion+channels"}]}