{"symbol":"PACRG","synonyms":["HAK005771","PARK2CRG","GLUP"],"name":"PARK2 co-regulated","description":"This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson\u0027s disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson\u0027s disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":135138,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/135138","proteins":[{"symbol":"PACRG_HUMAN","href":"/api/1.0/protein/PACRG_HUMAN"}],"hgncRootFamilies":[]}