{"symbol":"PACS1","synonyms":["SHMS","MRD17"],"name":"phosphofurin acidic cluster sorting protein 1","description":"This gene encodes a protein with a putative role in the localization of trans-Golgi network (TGN) membrane proteins. Mouse and rat homologs have been identified and studies of the homologous rat protein indicate a role in directing TGN localization of furin by binding to the protease\u0027s phosphorylated cytosolic domain. In addition, the human protein plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":55690,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/55690","proteins":[{"symbol":"PACS1_HUMAN","href":"/api/1.0/protein/PACS1_HUMAN"}],"hgncRootFamilies":[]}