{"symbol":"PAK2","synonyms":["PAK65","PAKGAMMA"],"name":"p21 protein (Cdc42/Rac)-activated kinase 2","description":"The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":5062,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5062","proteins":[{"symbol":"PAK2_HUMAN","href":"/api/1.0/protein/PAK2_HUMAN"}],"hgncRootFamilies":[]}